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PARP & DDR Inhibitors Summit 2022
课程概要
- Both PARP and kinase inhibitors may display a varying spectrum ofactivity in cells vs cell-free systems
- Previously uncharacterized interactions: PARP1/2 inhibitors may offerchemical starting points for lesser-studied mono-PARPs
- Patterns of chemical phylogeny can be established indicating potentialoff-target liabilities
- Residence time may be selectivity determinant for PARP inkibitors andshould be explored further