The human and mouse Lumit™m lL-1β lmmunoassays proved very usefulfor assessing a series of putative NLRP3 inflammasome inhibitors

• we provide rank order potency for five inhibitors
• we identified two putative inhibitors that do not appear to be true NLRP3 inhibitors

Combining the Lumit™ lL-1β Assays with the Caspase-Glo^® 1 Assay andthe NLRP3 Target Engagement demonstrates a link between targetbinding with functional outcomes for a mechanistic assessment ofinflammasome modulators